Skip to main content

Scientists conduct experiment to potentially cure HIV by editing Gene

Recently scientists show a big hope to get rid of HIV permanently through DNA modification. It now shows up researchers have effectively wiped out the HIV DNA in live mice by utilizing a technique known as Gene Editing. This technique is called as "CRISPR gene-editing technology ". The CRISPR  gene-editing technology allowed scientists to “cut out the bad genes and let the rest be”. 
This initial experiment seemed to have been generally effective, in spite of the fact that it is still excessively ahead of schedule to finish up this as a working solution.  Scientists at the Lewis Katz School of Medicine at Temple University  (LKSOM) and the University of Pittsburgh already proved that they can excise HIV DNA from the genomes of living animals to eliminate further infection permanently. To be more exact, the reality this technique works fine on a living animal is a noteworthy achievement. However,  scientists performed the feat in three different animal models,  including a "humanized" model in which mice were transplanted with  human immune cells and infected with the virus. In any case, that does not mean experiments on human beings will yield similar outcomes. To handle this issue, the group of researchers expects to attempt this technique on primates very soon.

A few researchers aim to modify genes made by immune cells that HIV usually infects — called T partner cells — so that the infection can't discover a route in. Others take an alternate tack: outfitting the T cells with gene-editing  instruments so they can look for and annihilate any HIV that infects them. At the point when HIV infects a T cell, its genome is embedded into the cell's DNA and captures its DNA-duplicating machinery to produce more duplicates of the virus. In any case, a T cell furnished with a DNA-shearing enzyme called Cas9, together with modified bits of RNA that guide the enzyme to a specific arrangement in the HIV genome, could discover, cut and disabled the intruder's genome.


The researchers exhibit that HIV-1 replication can be totally stopped and the virus eliminated from infected cells in animals gene editing technology, CRISPR/Cas9. The whole research work was led by Wenhui Hu, Associate Professor in the Center for Metabolic Disease Research and the Department of Pathology in the Department of Neuroscience) at LKSOM, Kamel Khalili, Professor and Chairman of the Department of Neuroscience, Director of the Center for Neurovirology, and Director of the Comprehensive NeuroAIDS Center at LKSOM and Won-Bin Young, Assistant Professor in the Department of Radiology at the University of Pittsburgh School of Medicine at the season of the exploration.

Dr  Wenhui Hu stated --
 "Our new study is more comprehensive. We confirmed the data from our previous work and have improved the  efficiency of our gene editing strategy. We also show that the strategy  is effective in two additional mouse models, one representing acute  infection in mouse cells and the other representing chronic, or latent,  infection in human cells." 
In the new study, this researcher group genetically inactivated HIV-1 in transgenic mice, diminishing the RNA articulation of viral genes by about 60 to 95 percent. They then tried their framework in mice intensely infected with EcoHIV, the mouse equivalent of human HIV-1.
Dr. Kamel Khalili stated that --
 "During acute infection, HIV actively replicates. With EcoHIV mice, we were able to investigate the ability of the  CRISPR/Cas9 strategy to block viral replication and potentially prevent  systemic infection.The excision efficiency of their strategy reached  96 percent in EcoHIV mice, providing the first evidence for HIV-1  eradication by prophylactic treatment with a CRISPR/Cas9 system. "
To decide the achievement of the technique, the researcher group measured levels of HIV-1 RNA and utilized a novel live bioluminescence imaging framework. Dr. Kamel Khalili stated that -
 "The imaging system, developed by Dr. Young while at the University of  Pittsburgh, pinpoints the spatial and temporal location of  HIV-1-infected cells in the body, allowing us to observe HIV-1  replication in real-time and to essentially see HIV-1 reservoirs in  latently infected cells and tissues," 

 "The next stage would be to repeat the study in primates, a more suitable  animal model where HIV infection induces disease, in order to further  demonstrate elimination of HIV-1 DNA in latently infected T cells and  other sanctuary sites for HIV-1, including brain cells," 
References :


Tags : Science, Medical, Health, News, Amazing News, HIV

This Post Was Published On My Steemit Blog. Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit 







Comments

Popular Posts (Last 7 Days)

Top 10 famous Abstract Art of all the time

Top 10 famous Abstract Art of all the time I love abstract arts. I believe that abstract art is not what you see , it’s what you think. Abstract art is the freedom of using colors, is the freedom of representing your thoughts in colors. Today, here I share top 10 famous abstract arts of all the time. Hope you’ll enjoy them. Number 10 : The Son Of Man by Rene Magritte image source & credit :  LINK Artist: René Magritte Media: Oil paint Created: 1964 Period: Surrealism Subject: René Magritte Number 09 : Garçon à la pipe by Pablo Picasso image source & credit :  LINK Artist: Pablo Picasso Dimensions: 1 m x 81 cm Created: 1905 Media: Oil paint Period: Picasso’s Rose Period Support: Canvas Number 08 : The Night Watch by Rembrandt image source & credit :  LINK Artist: Rembrandt Dimensions: 3.63 m x 4.37 m Created: 1642 Locations: Amsterdam Museum, Rijksmuseum Periods: Baroque, Dutch Golden Age Genres: Portrait, History pain

One Black & White Photograph Daily for 30 days - Day #25

green yard - behind of my village home Camera : Xiaomi Model : 2014818 Location : Bongaon, West Bengal, India Snap Taken : 14 March 2016 Tags : Black & White Photography, Flowers & Plants photography, Landscape photography, Nature, Photography,  This Post Was Published On My Steemit Blog . Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit  $3 Donation [Fixed] Donate $Any Amount

The Real Face Of India - Episode 133

The Real Face Of India - Episode#133 I believe that India is the most beautiful country in the world. In this series I show the real face of beautiful India. Half Dozen Photos of Natural Beauties Snap taken : 21 Mar 2018   Camera : SAMSUNG, Model : SM-A310N0 Other Episodes :  Episode#01 ,  Episode#02 ,  Episode#03 ,  Episode#04 ,  Episode#05 ,  Episode#06 ,  Episode#07 ,  Episode#08 ,  Episode#09 ,  Episode#10 ,  Episode#11 ,  Episode#12 ,  Episode#13 ,  Episode#14 ,  Episode#15 ,  Episode#16 ,  Episode#17 ,  Episode#18 ,  Episode#19 ,  Episode#20 ,  Episode#21 ,  Episode#22 ,  Episode#23 ,  Episode#24 ,  Episode#25 ,  Episode#26 ,  Episode#27 ,  Episode#28 ,  Episode#29 ,  Episode#30 ,  Episode#31 ,  Episode#32 ,  Episode#33 ,  Episode#34 ,  Episode#35 ,  Episode#36 ,  Episode#37 ,  Episode#38 ,  Episode#39 ,  Episode#40 ,  Episode#41 ,  Episode#42 ,  Episode#43 ,  Episode#44 ,  Episode#45 ,  Episode#46 ,  Episode#47 ,  Episode#48 ,  Episode#49 ,  Episode#50 , 

What I Learnt Today : 10 Unknown Amazing Facts About Animals - Part CXXXIII

  image credit (1) Japanese Macaques make snowballs for fun. (2) The chevrotain is an animal that looks like a tiny deer with fangs. (3) Turritopsis nutricula Immortal jellyfish is the only species known to live forever. (4) One million stray dogs and 500,000 stray cats live in New York City metropolitan area. Turritopsis nutricula Immortal jellyfish   image credit (5) Nine-banded armadillos always give birth to identical quadruplets. (6) The flying frog uses flaps of skin between its toes to glide. (7) It takes a sloth two weeks to digest its food.   Nine-banded armadillo   flying frogs   image credit (8) A narwhal tusk is actually an exaggerated front left tooth, and unlike most teeth, it's soft and sensitive on the outside with a tough interior. (9) Humpback whales create the loudest sound of any living creature. (10) The slowest mammal on earth is the tree sloth. It only moves at a speed of 6 feet (1.83 meters) per minute. sloth narwhal tusk   i

Before A Heavy Rainfall

I clicked at the exact time ; after about 5 minutes rain started Location : Dakshineswar, Kolkata Snap taken : 02 August 2016 Camera : Xiaomi ; model - 2014818 Tags : Photography, Nature, Landscape photography, Flowers & Plants photography, Sky,  This Post Was Published On My Steemit Blog . Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit  $3 Donation [Fixed] Donate $Any Amount

mathematics behind chess

Is there any relationship between supposing numerically and supposing in the round of Chess? At the end of the day, should a man having a dynamic personality in Mathematics turned out to be essentially a decent Chess player have aptitudes in Mathematics?  It is important to call attention to that because of the subject intricacy, our endeavors will be to clarify essential attributes of both  Science and Chess which have been postured by surely understood Mathematicians and Chess players. In like manner, we are not keen on uncovering truths, for instance, from the Theory of Knowledge, Psychology, Epistemology or going further into the specialized and complex parts of Chess.  In the first place, let us analyze a few characteristics of Mathernatics.  Individuals having poor involvement in Mathematics trust that knowing how to include, subtract, increase or separation empowers them to say that they could ace Mathematics. Others having some aptitude in performing fa

Camouflage Bee [Original Work]

I shoot this amazing photograph - a bee in Camouflage on sunflower ......... in a zoom shot ........ Tags : Flowers, Insects, Macro Photography, Nature, Photography, Flowers & Plants photography, Insects photography,  This Post Was Published On My Steemit Blog . Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit  $3 Donation [Fixed] Donate $Any Amount

great barrier reef

Tags :   Landscape photography, Nature, Ocean, Photography, Great barrier reef, Coral reef This Post Was Published On My Steemit Blog .  Earned : $00.04 SBD Converted to USD @1.32$ Rate = $0.0528 USD .  First Time heard about Steemit ? Click Here To Know...

Top 10 Bitcoin Price Predictions for 2018 to 2022

image credit Although many Bitcoin price analyzer says "Bitcoin price is truly unpredictable", but, there are always some price specialists who love to make their own price predictions in various ways. Here are top 10 Bitcoin price predictions for 2018 to 2022 : 10. $20,000 By December 2018 :: Predicted by Pantera Capital's 9. $25,000 By December 2018 :: Predicted by Fundstrat Global Advisors  8. $28,000 By  April 2018 :: Max Keiser 7. $35,000 – $60,000 By Next Block Reward Halving (   ETA date:   30 May 2020   ) :: Alistair Milne 6. $50,000 By December 2018 :: Anthony Pompliano 5. $75,000 By December 2018 :: John Pfeffer 4. $100,000 By December 2018 :: Kay Van-Petersen 3. $250,000 By 2022 :: Brian Kelly 2. $250,000+ By December 2022 :: Tim Draper 1. $1,000,000 By December 2020 :: John McAfee Source :  bitcoinist Tags : Bitcoin, Cryptocurrency, Crypto Markets, Money, Economics, News,  This Post Was Published On My Steemit Blog . Ple

Earn Bitcoin by playing free fun games (non gambling)

To earn bitcoin by playing free games is very exciting. Here I give a list of all games I searched on Google. 1.  SatoshiQuiz  :SatoshiQuiz is a quiz website where users win bitcoin for correctly answering questions from various categories.. You can earn 100 to 1000 satoshi per winning quiz.  Try the new android app and get 5000 satoshis.  Download   Min withdrawal amount is 11000 satoshis & Processed once every week on Sunday.1000 satoshi fees deducted per withdrawal to prevent abuse. Premium account fees is 100000 satoshis per month.   2.  Bitcoin Riddles  :Solve riddles presented in YouTube videos and if you are the first to get the correct answer you win a prize in BTC! Minimum withdrawal is 100 bits. After signup you will get free 10 bits.  3.  Sparkprofit  : Spark Profit aims to be the world's most rewarding app! It teaches you how to profitably trade on the financial markets, and pays you cash rewards when you do well. Platform : Windows, Mac, Android &
Back to Top