Skip to main content

Scientists conduct experiment to potentially cure HIV by editing Gene

Recently scientists show a big hope to get rid of HIV permanently through DNA modification. It now shows up researchers have effectively wiped out the HIV DNA in live mice by utilizing a technique known as Gene Editing. This technique is called as "CRISPR gene-editing technology ". The CRISPR  gene-editing technology allowed scientists to “cut out the bad genes and let the rest be”. 
This initial experiment seemed to have been generally effective, in spite of the fact that it is still excessively ahead of schedule to finish up this as a working solution.  Scientists at the Lewis Katz School of Medicine at Temple University  (LKSOM) and the University of Pittsburgh already proved that they can excise HIV DNA from the genomes of living animals to eliminate further infection permanently. To be more exact, the reality this technique works fine on a living animal is a noteworthy achievement. However,  scientists performed the feat in three different animal models,  including a "humanized" model in which mice were transplanted with  human immune cells and infected with the virus. In any case, that does not mean experiments on human beings will yield similar outcomes. To handle this issue, the group of researchers expects to attempt this technique on primates very soon.

A few researchers aim to modify genes made by immune cells that HIV usually infects — called T partner cells — so that the infection can't discover a route in. Others take an alternate tack: outfitting the T cells with gene-editing  instruments so they can look for and annihilate any HIV that infects them. At the point when HIV infects a T cell, its genome is embedded into the cell's DNA and captures its DNA-duplicating machinery to produce more duplicates of the virus. In any case, a T cell furnished with a DNA-shearing enzyme called Cas9, together with modified bits of RNA that guide the enzyme to a specific arrangement in the HIV genome, could discover, cut and disabled the intruder's genome.


The researchers exhibit that HIV-1 replication can be totally stopped and the virus eliminated from infected cells in animals gene editing technology, CRISPR/Cas9. The whole research work was led by Wenhui Hu, Associate Professor in the Center for Metabolic Disease Research and the Department of Pathology in the Department of Neuroscience) at LKSOM, Kamel Khalili, Professor and Chairman of the Department of Neuroscience, Director of the Center for Neurovirology, and Director of the Comprehensive NeuroAIDS Center at LKSOM and Won-Bin Young, Assistant Professor in the Department of Radiology at the University of Pittsburgh School of Medicine at the season of the exploration.

Dr  Wenhui Hu stated --
 "Our new study is more comprehensive. We confirmed the data from our previous work and have improved the  efficiency of our gene editing strategy. We also show that the strategy  is effective in two additional mouse models, one representing acute  infection in mouse cells and the other representing chronic, or latent,  infection in human cells." 
In the new study, this researcher group genetically inactivated HIV-1 in transgenic mice, diminishing the RNA articulation of viral genes by about 60 to 95 percent. They then tried their framework in mice intensely infected with EcoHIV, the mouse equivalent of human HIV-1.
Dr. Kamel Khalili stated that --
 "During acute infection, HIV actively replicates. With EcoHIV mice, we were able to investigate the ability of the  CRISPR/Cas9 strategy to block viral replication and potentially prevent  systemic infection.The excision efficiency of their strategy reached  96 percent in EcoHIV mice, providing the first evidence for HIV-1  eradication by prophylactic treatment with a CRISPR/Cas9 system. "
To decide the achievement of the technique, the researcher group measured levels of HIV-1 RNA and utilized a novel live bioluminescence imaging framework. Dr. Kamel Khalili stated that -
 "The imaging system, developed by Dr. Young while at the University of  Pittsburgh, pinpoints the spatial and temporal location of  HIV-1-infected cells in the body, allowing us to observe HIV-1  replication in real-time and to essentially see HIV-1 reservoirs in  latently infected cells and tissues," 

 "The next stage would be to repeat the study in primates, a more suitable  animal model where HIV infection induces disease, in order to further  demonstrate elimination of HIV-1 DNA in latently infected T cells and  other sanctuary sites for HIV-1, including brain cells," 
References :


Tags : Science, Medical, Health, News, Amazing News, HIV

This Post Was Published On My Steemit Blog. Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit 







Comments

Popular Posts (Last 7 Days)

What I Learnt Today : 10 Unknown Amazing Facts About Animals - Part CXXXIII

  image credit (1) Japanese Macaques make snowballs for fun. (2) The chevrotain is an animal that looks like a tiny deer with fangs. (3) Turritopsis nutricula Immortal jellyfish is the only species known to live forever. (4) One million stray dogs and 500,000 stray cats live in New York City metropolitan area. Turritopsis nutricula Immortal jellyfish   image credit (5) Nine-banded armadillos always give birth to identical quadruplets. (6) The flying frog uses flaps of skin between its toes to glide. (7) It takes a sloth two weeks to digest its food.   Nine-banded armadillo   flying frogs   image credit (8) A narwhal tusk is actually an exaggerated front left tooth, and unlike most teeth, it's soft and sensitive on the outside with a tough interior. (9) Humpback whales create the loudest sound of any living creature. (10) The slowest mammal on earth is the tree sloth. It only moves at a speed of 6 feet (1.83 meters) per minute. sloth narwhal tusk   i

mathematics behind chess

Is there any relationship between supposing numerically and supposing in the round of Chess? At the end of the day, should a man having a dynamic personality in Mathematics turned out to be essentially a decent Chess player have aptitudes in Mathematics?  It is important to call attention to that because of the subject intricacy, our endeavors will be to clarify essential attributes of both  Science and Chess which have been postured by surely understood Mathematicians and Chess players. In like manner, we are not keen on uncovering truths, for instance, from the Theory of Knowledge, Psychology, Epistemology or going further into the specialized and complex parts of Chess.  In the first place, let us analyze a few characteristics of Mathernatics.  Individuals having poor involvement in Mathematics trust that knowing how to include, subtract, increase or separation empowers them to say that they could ace Mathematics. Others having some aptitude in performing fa

Top 10 famous Abstract Art of all the time

Top 10 famous Abstract Art of all the time I love abstract arts. I believe that abstract art is not what you see , it’s what you think. Abstract art is the freedom of using colors, is the freedom of representing your thoughts in colors. Today, here I share top 10 famous abstract arts of all the time. Hope you’ll enjoy them. Number 10 : The Son Of Man by Rene Magritte image source & credit :  LINK Artist: René Magritte Media: Oil paint Created: 1964 Period: Surrealism Subject: René Magritte Number 09 : Garçon à la pipe by Pablo Picasso image source & credit :  LINK Artist: Pablo Picasso Dimensions: 1 m x 81 cm Created: 1905 Media: Oil paint Period: Picasso’s Rose Period Support: Canvas Number 08 : The Night Watch by Rembrandt image source & credit :  LINK Artist: Rembrandt Dimensions: 3.63 m x 4.37 m Created: 1642 Locations: Amsterdam Museum, Rijksmuseum Periods: Baroque, Dutch Golden Age Genres: Portrait, History pain

Well Protected 'Great Barrier Reef Corals' Are Now Destroyed

The clearing reefs becoming off 200 hot miles of remote Australian coastline — from Cairns to Cape Melville, home to sugar ranches and jump resorts — contained a portion of the minimum harmed corals developing in one of the world's best marine parks. Up to this point.  In dazzling new discoveries that have uncovered the restrictions of marine parks as protections against quick ecological change, more than half of the corals reviewed in extensive lumps of this immaculate stretch of the Great Barrier Reef are required to soon be dead.  "Reefs that are fit as a fiddle ought to admission better under environmental change," said John Pandolfi, a University of Queensland educator who added to prominent coral reviews, the aftereffects of which were discharged for this present week. "Be that as it may, for this situation, we discovered colossal occasions of coral mortality."  The coral passings took after extreme coral blanching, which was created by a

Dragon Pattern [An Original Design]

I design this virtual carpet - Dragon Pattern Dragon Pattern Tags : Abstract, Art, Design, Drawing, Painting,  This Post Was Published On My Steemit Blog . Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit  $3 Donation [Fixed] Donate $Any Amount

My Stereogram Collections - Part 4

what can you see ? reply in post ...   To know about Stereogram please, visit  https://en.wikipedia.org/wiki/Stereoscopy my first post of   stereogram collections - Part 1   my second post of   stereogram collections - Part 2 my third post of   stereogram collections - Part 3 Tags :   Funny, Images, Stereogram This Post Was Published On My Steemit Blog .  Earned : $05.42 SBD Converted to USD @1.01$ Rate = $5.4742 USD .  First Time heard about Steemit ? Click Here To Know...

Untitled 3

Tags : Life, Photography, Flood, This Post Was Published On My Steemit Blog . Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit  $3 Donation [Fixed] Donate $Any Amount

The health benefits of yoga

Yoga is a sort of stance and breathing activities. It unites physical and mental controls to accomplish peace of body and psyche, helping you unwind and oversee anxiety and tension. Conventional Yoga puts accentuation on conduct, eating regimen and contemplation. Yet, in the event that you're simply searching for better push administration—and not a whole way of life change, yoga can at present help. Yoga mentors step by step pick simpler to complex exercises for specialists. In any case, all specialists don't as a matter of course need the same sorts of practice.  The potential medical advantages of yoga are various and may include:  1. Stress lessening :  With its peaceful, exact developments, yoga draws your core interest far from your occupied, riotous day and towards quiet as you move your body through represents that require equalization and fixation.  2. Increased fitness :  As you learn and refine new postures, you may appreciate enhanced parity, adapt

macro photography of a strawberry

Tags :   Food, Fruits, Macro Photography, Photography, Fruits photography, Food photography This Post Was Published On My Steemit Blog .  Earned : $00.00 SBD Converted to USD @0.8943$ Rate = $00.00 USD .  First Time heard about Steemit ? Click Here To Know...

Alien 3D - My 3D modeling with poser [Download free this 3D model Here]

Today here I share one of my 3D model "Alien". I create this 3D object with the help of Poser Pro 2010. You may also download free this 3D model in 6 different formats - poser, 3D studio, lightwave, wavefront object etc. If this 3D model will be popular here then I'll make another posts for sharing my 3D models free. Here is also a preview video Now Download this 3D model :  Download Now   I hope you enjoy this :) Tags : 3D Models, Art, Graphics, Poser,  This Post Was Published On My Steemit Blog . Please, navigate to steemit and cast a free upvote to help me if you like my post. First Time heard about Steemit ? Click Here To Know Everything About Steemit  $3 Donation [Fixed] Donate $Any Amount
Back to Top